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Scientists have not too long ago recognized and succeeded in synthesizing conolidine, a purely natural compound that demonstrates promise as a powerful analgesic agent with a far more favorable security profile. Even though the actual system of action remains elusive, it can be at present postulated that conolidine may have quite a few biologic tar

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Importantly, these receptors have been observed to have been activated by a wide range of endogenous opioids at a concentration just like that observed for activation and signaling of classical opiate receptors. Consequently, these receptors ended up uncovered to get scavenging action, binding to and reducing endogenous amounts of opiates available

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